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Serum level analysis

 

After you click on the drug selection box,  you may select a drug model by either:

Clicking the scroll bar to scroll through the list of available drugs, or
Typing in a drug name. The program will match the available drug models with what you type, as you type it.

 

After the model is selected, you may change the target levels and target peak time.

 

Important: in order to simplify data entry the following assumptions are made.

If any one of the following conditions are not met, then the serum level analysis will likely be inaccurate:

Drug has been infused at a constant rate over the correct infusion time.
Drug has been administered at the correct dose and interval.
Administration and draw times are recorded accurately.

 

Select analysis method

Multiple analysis methods are available.  Choose the method which best fits your serum level data.

 

Method (click for picture)

Data required

Analysis used

Steady-state single point

A single timed level after a steady-state dose.

Bayesian

 

 

 

Steady-state peak/trough

A trough drawn before and a peak drawn after  a steady-state dose.

Sawchuk/Zaske

or Bayesian

 

 

 

Steady-state 2- or 3-point

2 or 3 serum levels drawn after a steady-state dose.

Sawchuk/Zaske

or Bayesian

 

 

 

First dose 2- or 3-point

2 or 3 serum levels drawn after an initial loading dose. Please note: this method assumes a pre-dose level of ZERO.  In other words, there must be NO DRUG on board when the loading dose is given.

Linear regression

 

 

 

Non-steady-state 3 point

A trough before the dose,  then a peak and trough after the dose.

Sawchuck/Zaske

 

 

 

Extended interval

For aminoglycosides only: a single timed level after a steady-state dose.

"Hartford nomogram"

 

After entering dose and serum level data, click the calculate button. The program performs a few simple checks of your data entry, if no results are displayed then you have entered inappropriate data.  If your data entry is within limits, the program will calculate and display the Kel, Vd, and the Ideal dosage regimen for the patient and model selected.  

 

You then enter a practical dose and interval.  The program will calculate and display an estimated steady-state peak and trough level.

 

After a dose and interval are entered, the Print and View Graph functions are enabled. Please Note: If you wish to have a serum level graph printed on your dosing consult, click View Graph then click the Save graph button.

 

Bayesian analysis is only available to registered users.

 

 

 

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