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After selecting a drug model you may modify any of the displayed model parameters (+/- 25% of default parameters):
Vd = DW x Vd L/kg (x CF)
Kel (or CL) = Nonrenal + [Renal x CrCl]
Note: default model parameters are changed with the drug model editor.
Please note that prospective pediatric dosing is weight-based instead of kinetic based, because of the inaccuracy of pediatric creatinine clearance methods.
EI dosing is enabled if:
Ideal dose calculation
Click the Calculate button to display the Kel, Vd, and the ideal dosing regimen for the patient and model selected.
You then enter a practical dose and interval. The program will calculate and display an estimated steady-state peak and trough level.
To view the dose in mg/kg, hover the mouse pointer over the dose input box.
After a dose and interval are entered, the Print and View Graph functions are enabled.
If you wish to have a serum level graph printed on your dosing consult, click the View Graph icon then click Save Graph.