Version history

• 1.1.0 - First beta version
• 2.1.0 - Second beta versoin
• 3.1.0 - First commercial release
• 3.2.1 - Features added/bugs fixed
  • Added monitoring form
  • Added print dialog with comments
• 3.3.1 - Features added/bugs fixed
  • Added consult table
  • Added report writer
  • Added serum level display for prospective EI
• 3.3.2 - Features added/bugs fixed
  • Added print preview
  • Added date picker to report writer
  • Improved serum level graph
• 3.3.3 - Features added/bugs fixed
  • Added Bayesian analysis
  • Added serum level display for prospective peds
  • Gender displayed on print-out
  • Bug fix: unable to reactivate patient
• 3.3.4- Features added/bugs fixed
  • Added international support for decimal separator
  • Added graph file cleanup code
  • Added support for 5 decimal place Kel constants
  • Added support for two word model names
  • Bug fix: CrCl method selection disabled
  • Bug fix: Vanco single point not accepted
• 3.3.5- Features added/bugs fixed
  • Added 'always index' to drug models edit window
  • Added Restore button to prospective dosing tab
  • Added range checking code to prospective dosing tab
  • Bug fix: Floating point error
  • Bug fix: 'model.mdx index not found' error
  • Bug fix: Graph not printing on some printers
• 3.3.6- Features added/bugs fixed
  • Added new fields to drug models database
  • Improved drug model editing window
  • Added range checking code to prospective dosing tab
  • Added another serum level analysis method: steady-state 2- or 3- points post-dose with optional Bayesian analysis.
  • Added steady-state proximity check.
• 3.3.7- Features added/bugs fixed
  • Bug fix: "Invalid floating point" error with Bayesian outliers.
• 3.3.8- Features added/bugs fixed
  • Added backup and restore database function.
  • Added copy model function to drug model editing window
  • Added extrapolated level display/printing.
• 3.3.9- Features added/bugs fixed
  • Added population analysis tool
  • Graph improved to show approach to steady-state
  • Backup improved to save and restore individual tables
  • Added ability to change consult header
  • Added physician lookup table
  • Added lookup function for active and inactive patient lists
  • Bug fix: duplicate record entry
  • Conduit: duplicate record entry fix
  • Conduit: added HotSync failure notice
• 3.3.10- Features added/bugs fixed
  • Added ability to enter fractional doses
• 3.3.11- Features added/bugs fixed
  • Added additional creatinine clearance methods
  • Added CL method for 1-compartment models
  • Added log in screen and access log for HIPAA compliance
  • Added PK/PD parameter calculation
• 3.3.11.3- Features added/bugs fixed
  • Improved multi-user support - File lock reduced
  • Improved mg% to IU conversion
  • Add C&G LBW to Other CrCl screen
  • Cap geriatric CrCl @ 100 instead of 120
  • Added web update
  • Improved time to SS estimation
  • Bug fix: EI dosing failed
• 3.3.12 - Features added/bugs fixed:
  • Improved EI dosing
• 3.3.13 - Features added/bugs fixed:
  • Implemented interface spec
  • Added interface with DripCharts
  • Added 'Pack Tables' reminder
• 3.3.14 - Features added/bugs fixed:
  • Improved LBW calculation in short statured individuals
• 3.3.15 - Features added/bugs fixed:
  • Improved interface function
  • Added multiple discharge function
  • Added delete patient function
• 3.3.16 - Features added/bugs fixed:
  • Removed Autoselect from patient name field
• 3.4.1 - Features added/bugs fixed:
  • Fixed: Tab order on model editor
  • Fixed: Model copy
  • Fixed: Target peak mask
  • Fixed: Delete without confirmation
  • Fixed: Reactivate pointer
  • Added: Other CrCl selection saved
  • Added: Exit prompt option
  • Added: Bayesian assay pattern settings
  • Added: Non-steady-state Bayesian analysis
  • Added: Discharge by date function
  • Added: Native Windows Mobile PDA version
• 3.4.2 - Features added/bugs fixed:
  • Added: continue current regimen option on consult print dialog
  • Fixed: Model copy (now also copies Bayesian parameters)
• 3.4.3 - Features added/bugs fixed:
  • Added: Loading dose to prosective method and serum level graph
  • Fixed: Trough out of range color change
  • Fixed: Help contents file pointer
• 3.4.4 - Features added/bugs fixed:
  • Fixed: Dynamic graph generation in prospective mode
• 3.4.5 - Features added/bugs fixed:
  • Added: IDMS creatinine MDRD method
• 3.4.6 - Features added/bugs fixed:
  • Improved: IDMS creatinine MDRD method
  • Improved: CrCl calculation for LBW infants
  • Added: legend to the EI nomogram graph
• 3.5.1 - Features added/bugs fixed:
  • Added Word doc template for Monitoring form printing
  • Added Time to consult print-out
  • Added Ability to edit checked comments
  • Added Resize to dialogs
  • Added Export data to reporting function
  • Added Graph to population analysis regression analysis.
  • Added Password to login for HI-TECH Act compliance
  • Added Barcode Code 128 to reports
  • Added Levels scheduler
  • Added Data encryption
  • Fixed Duplicate new user log in
  • Added Automatic retrieval of existing records active/inactive
  • Added "Copy to clipboard" button on consult preview for pasting into EMR
  • Fixed Patient list print error
  • Added User access (login) viewer
• 3.5.2 - Features added/bugs fixed:
  • Changed to tzdialog from kginput
  • Added check for duplicate model name
• 3.5.3 - Features added/bugs fixed:
  • Fixed status bar on Win2K
  • Fixed bar code position
• 3.5.4 - Features added/bugs fixed:
  • Added Patient search as default start up point
  • Updated SrCr fields to 2 decimal places
  • Added Print T90% and T95% to consult report
  • Added BMI to patient data tab
  • Added Mouse hover to view mg/kg
  • Added Overlay to start tab
  • Added Most recent used patient list
  • Added Search list
  • Added Option to Adjust CL to LBW.
  • Added Adjust SrCr for IDMS method & MinSrCr
  • Changed Single Bayesian to allow analysis of level outside of dosing interval.
• 3.5.5 - Features added/bugs fixed:
  • Fixed peak predict time.
  • Fixed "Type in MRN" to say "Name" instead.
• 3.5.6 - Features added/bugs fixed:
  • Added form position save to profile ini.
  • Added free text infusion time option.
  • Added realtime x,y graph scaling.
  • Added last used CrCl method saved.
  • Updated Bayesian routine.
  • Updated the updater stub.
• 3.5.7 - Features added/bugs fixed:
  • Added autocopy search spec to undelete window.
  • Fixed clear output after data edit.
  • Fixed new record should not preselect gender.
  • Fixed other CrCl methods.
• 3.5.8 - Features added/bugs fixed:
  • Fixed "Can't read file" error with restore function.
• 3.5.9 - Features added/bugs fixed:
  • Added copy to clipboard button to main print dialog.
  • Improved population analysis statistics.
  • Improved regression analysis plot.
  • Fixed proper name case.
  • Changed print command to call printer dialog first.
• 3.5.10 - Features added/bugs fixed:
  • Added save consult as PDF
  • Added flag to remove comma requirement in name
  • Improved Cpmax calculation
  • Improved report dialogs
  • Fixed earlier SrCr units entry
• 3.5.11 - Features added/bugs fixed:
  • Changed adjusted body weight for CrCl calc.
  • Added technical support dialog.
  • Updated default pk models.
  • Updated help file
• 3.5.12 - Features added/bugs fixed:
  • Added BMI to monitor and consult forms.
  • Added keyboard shortcuts.
  • Added background graph generation.
  • Fixed default Bayesian parameters.
  • Updated help file.
  • Added re-index function to db Maintenance
• 3.5.13 - Features added/bugs fixed:
  • Improved population analysis report.
  • Fixed comments not printing on consult.
• 3.5.14 - Features added/bugs fixed:
  • Added setup dialog.
  • Added obesity weight adjustment factor for CrCl.
  • Added check for update on startup.
  • Added check for presence of classic WinHelp.
  • Improved update checker.
  • Updated help file.
• 3.5.15 - Features added/bugs fixed:
  • Added virtual log paper tool.
  • Added automatic peak time calculation based on dist time.
  • Changed model editor to prevent name change.
  • Fixed gender choice on population analysis.
  • Fixed non-steady-state dialog.
  • Improved consult print-out: added method used, model selected.
  • Updated help file.
• 3.5.16 - Features added/bugs fixed:
  • Added point prediction tool.
  • Added detail to 'Outlier' dialog.
  • Added Bayesian goodness-of-fit to results dialog.
  • Improved Non-steady-state dialog.
  • Improved graph printing.
• 3.5.17 - Features added/bugs fixed:
  • Improvements to population analysis tool:
    • Added BMI analysis.
    • Added CL regression option.
    • Added Vd distribution density plot.
    • Automatic graph creation for Vd and Kel.
    • Added Mean Kel, Mean CrCl, and limits lines to regression graph.
  • Updated consults database to allow for increased Vd's due to obesity epidemic.
  • Fixed: uncheck 'print graph' did not suppress printing.
  • Fixed: prospective peds (wt based) model prediction.
  • Fixed: command line interface.
  • Improved F1 help system: now using chm format and xCHM for intranet display.
  • Added keyboard shortcuts: Esc to close patient list, Alt+X to close patient record.
  • Improved reporting tool: added filters for serum levels.
  • Improved CheckHtWt: broader range of limits.
  • Changed log-in form to display over main form so icon will show in taskbar.
  • Improved prospective consult: now saves current weight & CrCl.
  • Added Eureka error logging and online error reporting.
• 3.5.18 - Features added/bugs fixed:
  • Added [Pk/PD] shortcut button to dosing recommendation frames.
  • Fixed barcode options on print and settings dialogs.
  • Increased default form size.
  • Added "busy" cursor to patient search, grid population routine.
  • Improved intranet help topic selection.
• 3.5.19 - Features added/bugs fixed:
  • Fixed 'Invalid float' error.
  • Fixed ini write error.
  • Fixed view history error.
  • Fixed range error check.
  • Added icons to menu tree.
• 3.5.20 - Features added/bugs fixed:
  • Renamed Non-steady-state to Pre-steady-state.
  • Added steady-state status to consult.
  • Fixed missing dosing weight on consult.
  • Fixed population analysis regression graph Y scale.
  • Updated help file.
• 3.5.21 - Features added/bugs fixed:
  • Added targeted AUC dosing dialog
  • Added AUC to consult in analysis section
  • Added predicted AUC (or PKPD) to consult in recomendation section
  • Added predicted AUC display to screen below peak and trough
  • Added "kg/m2" to BMI display & print-out
  • Fixed window appearing off screen
  • Fixed Export pop analysis "No matching records found" (but saves)
  • Fixed Retro Pk/Pd calc error
  • Updated help file.
• 3.5.22 - Features added/bugs fixed:
  • Added hint to display T90% and T95% when mousing over PK parameter frames
  • Fixed graphing for 90 min infusion with 8 hr interval.
  • Fixed AUC/MIC ratio does not change when dose changed.
  • Disabled minimize button from print preview screens.
• 3.5.23 - Features added/bugs fixed:
  • Fixed graphing for loading dose.
• 3.5.24 - Features added/bugs fixed:
  • Fixed SS 2-3 point Bayesian.
  • Improved BMI out-of-range for peds.
  • Improved Pk/Pd routines.
• 3.5.25 - Features added/bugs fixed:
  • Improved default Blank_PK_monitor.doc
  • Added choice of population model or patient history for prospective dosing
  • Added choice of population model or patient history for Bayesian analysis
  • Added patient details to population analysis export table
• 3.5.26 - Features added/bugs fixed:
  • Improved choice of population model or patient history for Bayesian analysis.
  • Added Bayesian analysis export dialog.
• 3.5.27 - Features added/bugs fixed:
  • Changed population analysis selection to full model name.
  • Added albumin field to patient.dbf's.
  • Added albumin field to models.dbf. For future use, stay tuned.
  • Fixed crash that occurs when someone intentionally and inexplicably clears out the calculated CrCl.
  • Increased comment space in the consult print-out because some wish to write a 500 word essay.

  January 2021

• 3.5.28 - Features added/bugs fixed:
  • Allow trough time outside of dosing interval.
  • Added more specific checks to serum level entry.
  • Added AUC equations to help file.

To update your APK© program please use the built-in web update function

This function will will query, download, and install program updates from the RxKinetics web site (a live connection to the internet is required).

How to update via the built-in update function

1. Click Help on the program menu tree
2. Click Check for update

   

3. Follow the screen prompts