APK update

APK for Windows version 3.5.16 is available. Highlights include:

  • Added a point prediction tool.
  • Improved the ‘Outlier’ message dialog.
  • Added a goodness-of-fit indicator to the Bayesian results dialog.
  • Improved the ‘Non-steady-state’ message dialog.
  • Improved the serum level graph print-out.
  • Updated the help file.

Point prediction tool
Provides serum level prediction at any point within the dosing regimen. I find this useful for timing off-schedule doses and for evaluating non-steady-state levels.
apk_predict

Improved outlier message
Added detail to the Bayesian outlier message. Here is the old message:

And here is the improved message:

Goodness-of-fit indicator
A goodness-of-fit indicator was added to the Bayesian results dialog. This parameter is used to evaluate the reliability of the serum level analysis. The following parameters are included in the test:

  • Initial SS < 5
  • Final SS < 0.5
  • Final Vd SD < Model Vd SD
  • Final Kel SD < Model Kel SD
  • Predicted level = Measured level

If all 5 parameters are true, the measurement-to-model fit is excellent; 4/5 is a good fit; 3/5 is a fair fit; less than 3 is a poor fit.

Improved ‘Non-steady-state’ dialog
The previous dialog was wordy and vague:

The new dialog is simpler with clear choices:

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