Digoxin precautions

 

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1.   Proper timing of serum sampling is critical.

Serum samples should be drawn just prior to the daily dose and no sooner than six hours after administration of the drug.

 

2.   Factors affecting digoxin pharmacokinetics

Factors which predispose to digoxin toxicity:

Hypokalemia, hypomagnesemia, coronary artery disease, cor pulmonale, uncorrected hypothyroidism, renal dysfunction, and interacting drugs which decrease digoxin clearance (quinidine, spironolactone, and verapamil).

Factors which predispose to suboptimal clinical response:

Hyperkalemia, uncorrected hyperthyroidism, interacting drugs which delay or prevent oral absorption (antacids, cholestyramine, metoclopramide).

 


See also:

Introduction

Monitoring parameters

Pharmacokinetic formulas

Bibliography

 

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