Model data

 

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bm5

 

Model types

 

There are eight available model types:

 

1

One-compartment model

2

One-compartment model or dosing table

3

Two-compartment model

4

Two-compartment model or dosing table

5

Dosing table

6

Digoxin

7

Theophylline

8

Heparin

 

Model fields

Some fields are not applicable to all model types, fields with a grey background are not applicable to the current model type.  The following table describes the fields that are associated with each drug model:

 

Field

Description

1

2

3

4

5

6

7

Drug name

Name of model

(must be a unique name)

X

X

X

X

X

X

X

Vd peripheral

Vd peripheral compartment

(L/kg of dosing weight

X

X

X

X

 

X

X

Age correction for elderly

Vd correction for elderly patients

(age > 65 years)

X

X

X

X

 

 

 

Wt correction for obesity

Use to calculate dosing weight:

DW  =  LBW + [CF x (ABW-LBW)]

X

X

X

X

 

 

X

Target PK

Target peak level, if applicable

X

X

X

X

 

 

 

Peak time

Time in minutes, after the end of the infusion, when the target peak is to be targeted.

X

X

X

X

 

 

 

Target TR

Target trough level

X

X

X

X

 

X

X

Infusion

Default time of infusion (minutes)

X

X

X

X

 

X

X

Vd central

Vd central compartment (L/kg)

 

 

X

X

 

 

 

Kel calc or

CL calc

Select what is calculated by the equation:

  Nonrenal + (CrCl x Renal)

Elimination rate (Kel) or

Clearance (CL)

X

X

 

 

 

 

 

Renal

Renal portion of CL/Kel equation:

CL/Kel = Nonrenal + (CrCl x Renal)

X

X

X

X

 

X

X

Nonrenal

Nonrenal portion of CL/Kel equation:

CL/Kel = Nonrenal + (CrCl x Renal)

X

X

X

X

 

X

X

K12

Distribution constant central to periph

 

 

X

X

 

 

 

K21

Distribution constant periph to central

 

 

X

X

 

 

 

Max dose

Max recommended daily dose

(mg/kg/day)

X

X

X

X

 

X

X

EI dose

Mg/kg dose for extended interval dosing of aminoglycosides

X

 

 

 

 

 

 

MIC

Default minimum inhibitory concentration

X

X

X

X

 

 

 

SD Vd

Population Vd, standard deviation

(needed for Bayesian analysis)

X

 

X

 

 

 

 

SD Kel/Cl

Population Kel/Cl, standard deviation

(needed for Bayesian analysis)

X

 

X

 

 

 

 

SD CP1

Serum level standard deviation*

(needed for Bayesian analysis)

X

 

X

 

 

 

 

SD CP2

Serum level standard deviation*

(needed for Bayesian analysis)

X

 

X

 

 

 

 

SD CP3

Serum level standard deviation*

(needed for Bayesian analysis)

X

 

X

 

 

 

 

SD CP fixed

Serum level standard deviation*

(needed for Bayesian analysis)

X

 

X

 

 

 

 

Dosing table

Dosing table

 

X

 

X

X

 

 

Care plan

Pharmaceutical care plan

X

 

X

 

 

X

X

 

*Serum level SD is used to calculate serum assay error with a second order polynomial equation.  See Bayesian principles section for more detailed information.

 

 

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