﻿ Other creatinine clearance methods
 Other CrCl Methods
 This window is used to select alternate creatinine clearance methods.   Select the calculation method, then "Copy" to transfer the value to the patient data tab.   Click "Cancel" to close the window without copying the value to the patient data tab.   Cockcroft and Gault ABW This variation of the C&G equation uses Adjusted Body Weight.  The degree of adjustment may be changed on the Setup window. CrCl Males = ABW(140 - Age) / (SCr x  72) CrCl Females = 85% of male value   Cockcroft and Gault TBW This variation of the C&G equation uses Total Body Weight.  Be aware however, that this tends to over-estimate CrCl in larger patients. CrCl Males = TBW(140 - Age) / (SCr x  72) CrCl Females = 85% of male value   Cockcroft and Gault Normalized Removes weight from the C&G equation.  Some find this variation useful in patients whose body size is substantially different from average. CrCl Males = (140 - Age) / SCr CrCl Females = 85% of male value   Jelliffe 1973 Weight is not used in this equation either, therefore, some find this method useful in patients whose body size is substantially different from average: CrCl Males = 98 - (0.8 x (Age-20)) / Scr CrCl Females = 90% of male value   Jelliffe Multi-step This method corrects for rising serum creatinine and is most useful in patients with unstable renal function.  Please see the Renal formulas topic for an explanation of this equation.   MDRD (abbreviated) Derived from a large study of patients with a wide range of kidney function.  Some feel this is a more accurate GFR method for the average adult. GFR Males = exp[ 5.228 - ( 1.154 x  log{­SCr} )  - ( 0.203  x  log{­Age} ) GFR Female = 74.2% of male value For African Americans multiply by 1.21   It is important to note that MDRD calculates GFR which does not directly correlate to CrCl   Salazar and Corcoran Derived from a study of obese patients.  Some recommend this method for obese patients instead of the standard equations. CrCl Males  =  {­ ( 137 - Age ) x [ ( 0.285 x Wt)  + (12.1 x Ht^2 )] }  /  (51 x SCr) CrCl Females  = {­ ( 146 - Age ) x [ ( 0.287 x Wt)  + (9.74 x Ht^2 )] }  /  (60 x SCr)   See also: Introduction Monitoring parameters Precautions Renal formulas Bibliography