Other CrCl Methods

 

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This window is used to select alternate creatinine clearance methods.

 

Select the calculation method, then "Copy" to transfer the value to the patient data tab.

 

Click "Cancel" to close the window without copying the value to the patient data tab.

 

Cockcroft and Gault ABW

This variation of the C&G equation uses Adjusted Body Weight.  The degree of adjustment may be changed on the Setup window.

CrCl Males = ABW(140 - Age) / (SCr x  72)

CrCl Females = 85% of male value

 

Cockcroft and Gault TBW

This variation of the C&G equation uses Total Body Weight.  Be aware however, that this tends to over-estimate CrCl in larger patients.

CrCl Males = TBW(140 - Age) / (SCr x  72)

CrCl Females = 85% of male value

 

Cockcroft and Gault Normalized

Removes weight from the C&G equation.  Some find this variation useful in patients whose body size is substantially different from average.

CrCl Males = (140 - Age) / SCr

CrCl Females = 85% of male value

 

Jelliffe 1973

Weight is not used in this equation either, therefore, some find this method useful in patients whose body size is substantially different from average:

CrCl Males = 98 - (0.8 x (Age-20)) / Scr

CrCl Females = 90% of male value

 

Jelliffe Multi-step

This method corrects for rising serum creatinine and is most useful in patients with unstable renal function.  Please see the Renal formulas topic for an explanation of this equation.

 

MDRD (abbreviated)

Derived from a large study of patients with a wide range of kidney function.  Some feel this is a more accurate GFR method for the average adult.

GFR Males = exp[ 5.228 - ( 1.154 x  log{­SCr} )  - ( 0.203  x  log{­Age} )

GFR Female = 74.2% of male value

For African Americans multiply by 1.21

 

It is important to note that MDRD calculates GFR which does not directly correlate to CrCl

 

Salazar and Corcoran

Derived from a study of obese patients.  Some recommend this method for obese patients instead of the standard equations.

CrCl Males  =  {­ ( 137 - Age ) x [ ( 0.285 x Wt)  + (12.1 x Ht^2 )] }  /  (51 x SCr)

CrCl Females  = {­ ( 146 - Age ) x [ ( 0.287 x Wt)  + (9.74 x Ht^2 )] }  /  (60 x SCr)

 


See also:

Introduction

Monitoring parameters

Precautions

Renal formulas

Bibliography

 

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