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Comparative creatinine clearance calculator

Disclaimer: the objective of this calculator is to demonstrate the different results obtained from various published creatinine clearance equations for a given set of patient data. It is intended for teaching purposes only.

Inputs

Age     years
Height    
Weight    
Gender      
SCr     mg/dl
 
 

Output

Method CrCl (ml/min)
Cockcroft and Gault Lean BWEq 1 0
Cockcroft and Gault Adjusted BWEq 2 0
Cockcroft and Gault Total BWEq 3 0
Cockcroft and Gault NormalizedEq 4 0
Jelliffe bedside methodEq 5 0
Jelliffe multi-step methodEq 6 0
MDRD (calculates GFR, not CrCl)Eq 7 0
Salazar and CorcoranEq 8 0
 

Equations

  1. Cockcroft and Gault LBW
    CLCR Male = (Weight x [140 - Age]) / (SrCr x 72)
    CLCR Female = 85% of male value
    . . . where SrCr is the most recent serum creatinine.
    . . . Weight = Lean Body Weight (LBW)
     
  2. Cockcroft and Gault Adjusted BW
    Same as above where Weight = Adjusted Body Weight (ABW):
    If Total Body Weight (TBW) > LBW then:
    ABW = LBW + (0.4 x [TBW - LBW])
     
  3. Cockcroft and Gault Total BW
    Same as above where Weight = Total Body Weight
     
  4. Cockcroft and Gault normalized
    CLCR Male = (140 - Age) / SrCr
    CLCR Female = 85% of male value

     
  5. Jellife bedside method
    CLCR Male = (98 - [0.8 x (Age - 20)]) / SrCr
    CLCR Female = 90% of male value

     
  6. Jellife multi-step
    1. Estimate urinary creatinine excretion rate (E)
      E (Male) = LBW x (29.305 -[0.203 x (age)])
      E (Female) = LBW x (25.3 -[0.18 x (age)])
       
    2. Calculate normalized creatinine clearance (CLCR)
      CLCR/1.73 M2 = (E * 0.12) / (SrCr * BSA)
      . . . where BSA is body surface area in M2

     
  7. MDRD
    GFR Male = exp[ 5.228 - ( 1.154 x log{SrCr} ) - ( 0.203 x log{Age} )
    GFR Female = 74.2% of male value
    Correct to BSA / 1.73
     
  8. Salazar and Corcoran
    CLCR Male = {(137 - Age) x [(0.285 x Wt) + (12.1 x Ht2)]} / (51 x SrCr)
    CLCR Female = {(146 - Age) x [(0.287 x Wt) + (9.74 x Ht2)]} / (60 x SrCr)
    . . . Wt is the current weight in kg
    . . . Ht is height in meters

References

  1. Lott RS, Hayton WL. Estimation of Creatinine Clearance from Serum Creatinine Concentration - a review. Drug Intell Clin Pharm 1978;12:140-150.
     
  2. Rhodes PJ, et al. Evaluation of Eight Methods for Estimating Creatinine Clearance in Men. Clin Pharm. 1987;6:399-406.
     
  3. Chow MS, Schweizer R. Estimation of Creatinine Clearance in Patients with Unstable Serum Creatinine Concentrations: Comparison of Multiple Methods. Drug Intell Clin Pharm 1985;19:385-390.
     
  4. Jelliffe RW, Jelliffe SM. Estimation of creatinine clearance in patients with unstable renal function. (revised). Originally published: A computer program for estimation of creatinine clearance from unstable serum creatinine concentration. Math Biosci. 14:17-24 (June) 1972.
     
  5. Salazar DE, Corcoran GB. Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass. Am J Med. 1988 Jun;84(6):1053-60. [ PubMed ]
     
  6. Devine Ben. Gentamicin therapy. Drug Intell Clin Pharm 1974;8:650-6.
     
  7. Cockroft D.W., Gault M.H. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41. [ PubMed ]
     
  8. Levey AS, Greene T, Kusek JW, Beck GJ. A simplified equation to predict glomerular filtration rate from serum creatinine. J Am Soc Nephrol 11:A0828, 2000 (abstr)
     
  9. Winter, et al. Impact of various body weights and serum creatinine concentrations on the bias and accuracy of the Cockcroft-Gault equation. Pharmacotherapy 2012;32(7):604-612.

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