### Comparative creatinine clearance calculator

Disclaimer: the objective of this calculator is to demonstrate the different results obtained from various published creatinine clearance equations for a given set of patient data. It is intended for teaching purposes only.

#### Inputs

 Age years Height cm in Weight kg lb Gender Male Female SCr mg/dl

#### Output

 Method CrCl (ml/min) Cockcroft and Gault Lean BWEq 1 0 Cockcroft and Gault Adjusted BWEq 2 0 Cockcroft and Gault Total BWEq 3 0 Cockcroft and Gault NormalizedEq 4 0 Jelliffe bedside methodEq 5 0 Jelliffe multi-step methodEq 6 0 MDRD (calculates GFR, not CrCl)Eq 7 0 Salazar and CorcoranEq 8 0

#### Equations

1. Cockcroft and Gault LBW
CLCR Male = (Weight x [140 - Age]) / (SrCr x 72)
CLCR Female = 85% of male value
. . . where SrCr is the most recent serum creatinine.
. . . Weight = Lean Body Weight (LBW)

2. Cockcroft and Gault Adjusted BW
Same as above where Weight = Adjusted Body Weight (ABW):
If Total Body Weight (TBW) > LBW then:
ABW = LBW + (0.4 x [TBW - LBW])

3. Cockcroft and Gault Total BW
Same as above where Weight = Total Body Weight

4. Cockcroft and Gault normalized
CLCR Male = (140 - Age) / SrCr
CLCR Female = 85% of male value

5. Jellife bedside method
CLCR Male = (98 - [0.8 x (Age - 20)]) / SrCr
CLCR Female = 90% of male value

6. Jellife multi-step
1. Estimate urinary creatinine excretion rate (E)
E (Male) = LBW x (29.305 -[0.203 x (age)])
E (Female) = LBW x (25.3 -[0.18 x (age)])

2. Calculate normalized creatinine clearance (CLCR)
CLCR/1.73 M2 = (E * 0.12) / (SrCr * BSA)
. . . where BSA is body surface area in M2

7. MDRD
GFR Male = exp[ 5.228 - ( 1.154 x log{SrCr} ) - ( 0.203 x log{Age} )
GFR Female = 74.2% of male value
Correct to BSA / 1.73

8. Salazar and Corcoran
CLCR Male = {(137 - Age) x [(0.285 x Wt) + (12.1 x Ht2)]} / (51 x SrCr)
CLCR Female = {(146 - Age) x [(0.287 x Wt) + (9.74 x Ht2)]} / (60 x SrCr)
. . . Wt is the current weight in kg
. . . Ht is height in meters

#### References

1. Lott RS, Hayton WL. Estimation of Creatinine Clearance from Serum Creatinine Concentration - a review. Drug Intell Clin Pharm 1978;12:140-150.

2. Rhodes PJ, et al. Evaluation of Eight Methods for Estimating Creatinine Clearance in Men. Clin Pharm. 1987;6:399-406.

3. Chow MS, Schweizer R. Estimation of Creatinine Clearance in Patients with Unstable Serum Creatinine Concentrations: Comparison of Multiple Methods. Drug Intell Clin Pharm 1985;19:385-390.

4. Jelliffe RW, Jelliffe SM. Estimation of creatinine clearance in patients with unstable renal function. (revised). Originally published: A computer program for estimation of creatinine clearance from unstable serum creatinine concentration. Math Biosci. 14:17-24 (June) 1972.

5. Salazar DE, Corcoran GB. Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass. Am J Med. 1988 Jun;84(6):1053-60. [ PubMed ]

6. Devine Ben. Gentamicin therapy. Drug Intell Clin Pharm 1974;8:650-6.

7. Cockroft D.W., Gault M.H. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41. [ PubMed ]

8. Levey AS, Greene T, Kusek JW, Beck GJ. A simplified equation to predict glomerular filtration rate from serum creatinine. J Am Soc Nephrol 11:A0828, 2000 (abstr)

9. Winter, et al. Impact of various body weights and serum creatinine concentrations on the bias and accuracy of the Cockcroft-Gault equation. Pharmacotherapy 2012;32(7):604-612.