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1. Monitoring parameters:
Obtain levels 24 hours after initiating therapy, at steady state (approximately four half-lives), and every 2 to 3 days. For extended interval dosing method, obtain mid-interval drug level 6 to 14 hours after the initial dose and repeat drug level 1-2 times weekly. Patients with fluid shifts may need more frequent monitoring.
Measure every two days, or every day in unstable renal function.
Weigh patient every two to seven days.
Measure and monitor urine output daily.
2. Therapeutic serum concentrations (mcg/ml)
Serious infection: 6-8
Life-Threatening infection: 8-10
Serious infection: 0.5-1.5
Life-Threatening infection: 1- <2
Serious infection: 20-25
Life-Threatening infection: 25-30
Serious infection: 1-4
Life-Threatening infection: 4-8
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