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How to enter a drug model
Ampicillin 1-compartment model
- Start the Edit drug model function by clicking File then
Edit drug models from the menu bar.
- To add a new model, click the add icon ( + ) on the database navigation bar.
- Enter the following data in the appropriate fields. You may, of course, use numbers for Vd and Kel which are better suited for your patients.
| Field | Data | Notes |
|---|---|---|
| Drug name | Ampicillin | Must be a unique name |
| Vd (L/kg) | 0.26 | Volume of distribution (L/kg) |
| CF for Vd | 0.4 | Vd correction for obesity |
| Renal Kel | .0064 | From the Kel equation Kel = Nonrenal + (CrCl x Renal) |
| Nonrenal Kel | .058 | From the Kel equation Kel = Nonrenal + (CrCl x Renal) |
| Target peak | 50 | Target peak level |
| Peak predict time | 0 | Time, after the end of the infusion, that you will be targeting your peak. This is usually set to zero, unless you are modeling a drug with a long distribution time, e.g., vancomycin. |
| Target trough | 5 | Target trough level |
| Infusion time | 30 | Length of infusion in minutes |
| EI Dose | 0 | Dose for extended interval ("once-a-day") AG dosing. Enter zero to suppress. |
| Pediatric dose (mg/kg) | 50 | Applies if age is 8 days to 11 years |
| Pediatric Interval (hours) | 6 | |
| Neonatal dose (mg/kg) | 50 | Applies if age is 1 to 7 days |
| Neonatal interval (hours) | 12 | |
| Permit serum level analysis | (leave unchecked) | You would check this if your drug model has a routine serum level assay, e.g., AG's and vanco. |
For more information on building models "from scratch", see this tutorial:
