About this calculator
Demonstrates the different results obtained from various published creatinine clearance (CrCl) equations for a given set of patient data. This app is intended for teaching purposes only. For a detailed discussion see the Renally Excreted Drugs page.
- Input validation is limited — physiologically impossible values could be entered.
- A common error is not selecting the correct units for Height (cm vs in) or Weight (kg vs lb).
- Click Calculate after entering or changing any values.
Patient Parameters
Enter patient data below
years
mg/dl
Results — CrCl (ml/min)
| Method | CrCl |
|---|---|
| Cockcroft & Gault — Lean BW Eq 1 | — |
| Cockcroft & Gault — Adjusted BW Eq 2 | — |
| Cockcroft & Gault — Total BW Eq 3 | — |
| Cockcroft & Gault — Normalized Eq 4 | — |
| Jelliffe bedside method Eq 5 | — |
| Jelliffe multi-step method Eq 6 | — |
| Salazar & Corcoran Eq 7 | — |
| CKD-EPI (2021) (calculates eGFR, not CrCl) Eq 8 | — |
Equations
- Cockcroft and Gault LBW
CLCR Male = (Weight × [140 − Age]) / (SrCr × 72)
CLCR Female = 85% of male value
Weight = Lean Body Weight (LBW) - Cockcroft and Gault Adjusted BW
Same as above where Weight = Adjusted Body Weight (ABW):
If TBW > LBW: ABW = LBW + (0.4 × [TBW − LBW]) - Cockcroft and Gault Total BW
Same as above where Weight = Total Body Weight - Cockcroft and Gault Normalized
CLCR Male = (140 − Age) / SrCr
CLCR Female = 85% of male value - Jelliffe bedside method
CLCR Male = (98 − [0.8 × (Age − 20)]) / SrCr
CLCR Female = 90% of male value - Jelliffe multi-step
i. E (Male) = LBW × (29.305 − [0.203 × Age])
E (Female) = LBW × (25.3 − [0.18 × Age])
ii. CLCR/1.73 M2 = (E × 0.12) / (SrCr × BSA) - Salazar and Corcoran
CLCR Male = {(137 − Age) × [(0.285 × Wt) + (12.1 × Ht2)]} / (51 × SrCr)
CLCR Female = {(146 − Age) × [(0.287 × Wt) + (9.74 × Ht2)]} / (60 × SrCr)
Wt in kg, Ht in meters - CKD-EPI (2021) Included for comparison only.
eGFR should not be substituted for CrCl in pk modeling.
eGFR = 142 × min(Scr/κ, 1)α × max(Scr/κ, 1)-1.200 × 0.9938Age [ × 1.012 if female ]
κ (Kappa): 0.7 for females, 0.9 for males
α (Alpha): -0.241 for females, -0.302 for males
References
- Lott RS, Hayton WL. Estimation of Creatinine Clearance from Serum Creatinine Concentration — a review. Drug Intell Clin Pharm 1978;12:140-150.
- Rhodes PJ, et al. Evaluation of Eight Methods for Estimating Creatinine Clearance in Men. Clin Pharm. 1987;6:399-406.
- Chow MS, Schweizer R. Estimation of Creatinine Clearance in Patients with Unstable Serum Creatinine Concentrations. Drug Intell Clin Pharm 1985;19:385-390.
- Jelliffe RW, Jelliffe SM. Estimation of creatinine clearance in patients with unstable renal function. Math Biosci. 14:17-24, 1972.
- Salazar DE, Corcoran GB. Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass. Am J Med. 1988;84(6):1053-60. [PubMed]
- Devine Ben. Gentamicin therapy. Drug Intell Clin Pharm 1974;8:650-6.
- Cockroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41. [PubMed]
- Winter MA, et al. Impact of various body weights and serum creatinine concentrations on the bias and accuracy of the Cockcroft-Gault equation. Pharmacotherapy 2012;32(7):604-612.
- CKD-EPI Creatinine Equation (2021) National Kidney Foundation.