Renal precautions

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1. The following conditions may falsely elevate serum creatinine, thereby falsely decreasing the creatinine clearance.

•	Muscular diseases

•	dehydration

•	cephalosporins

•	cimetidine

2. The following conditions may falsely decrease serum creatinine, thereby falsely elevating the creatinine clearance.

•	small muscle mass (due to atrophy, cachexia, or amputation)

•	liver dysfunction