Serum level analysis


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Click this tab or use the Keyboard shortcut Alt+L to perform serum level analysis.  Data entry fields have a white background, calculated fields which cannot be edited have a grey or yellow background.



Data entry

A cue card displays on-screen instructions for each data entry field.

Dates must be entered in 4 digit year format.  If you experience problems entering dates, see the Getting Started section of the help file for more information.
Shortcut: Press the "T" key while in a date field to automatically enter Today's date.
Shortcut: Press the "P" key while in a date field to copy the previous date.
Tip: Use the left and right arrow keys to move between day, month and year fields.
Times must be entered in 24 hour military format, acceptable range is 00:00 to 23:59.



Select analysis method

For 1- compartment drugs there are several analysis methods supported  (click for a pictorial of required data):

A single post-dose level.
Traditional peak and trough level analysis,  trough before and peak after a steady-state dose.
2- and 3-point post dose analysis, levels drawn after a loading dose, e.g., "Zaske kinetics".
2- and 3-point post dose analysis, levels drawn after a dose.
3-point non-steady-state method with a trough drawn before the dose, and a peak and mid-interval level drawn after the peak.
Extended interval method for aminoglycosides, a random level drawn 6-16 hours after the start of the infusion.


For 2 compartment drugs administered by intermittent infusion there are three options for analyzing level data.

A single steady-state level may be analyzed with the Bayesian algorithm.
Traditional peak and trough level analysis, drawn before and after a steady-state dose.
3-point non-steady-state method where a steady-state trough before the dose, a peak, and mid-interval level after the peak are drawn.


Serum level requirements

Program requirements for serum level data:

1-compartment Bayesian methods do not require steady-state level(s), although accuracy is greatly improved with a steady-state level.
2-compartment Bayesian methods require steady-state level(s).
Digoxin requires a steady-state trough level.
Heparin requires a steady-state aPTT measurement.
Theophylline, either a steady-state level or non-steady-state levels if specific conditions are met.


Calculate parameters and dose

After serum level data entry is completed, click the Calculate button.  The program then calculates an "ideal" dose and interval.  Also at this time, serum level data is saved for future retrieval.


Enter dose

The user then enters a practical dose and interval and the program calculates projected serum levels.  At this point, pressing the tab key will loop between the dose and interval inputs so that user may enter and view the outcome of different dosing regimens, allowing one to find the best dose for the patient.


Retrieve levels

Click the Retrieve button to view a list of previous serum level sets for the current model and patient.


See also:




Renally excreted drugs





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