WBC and total lymphocytes


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Normal: Above 1800



The total lymphocyte count reflects the number of circulating lymphocytes, most of which are T cells. Tissues generating T cells are very sensitive to malnutrition and undergo involution with a decrease in lymphocyte production.  TLC is estimated from WBC and differential: (% lymphocytes X total WBC) / 100.


Low TLC: Less than 800


Malnutrition, poor protein intake.
Acute infections and illnesses.
Cancer, leukemia.
Immunodeficiency syndromes
Medications: immunosuppressants, corticosteroids.



Low  total lymphocyte count is not associated with specific symptoms or signs.



Mild deficit:        1200 to 2000

Moderate deficit        800 to 1200

Severe deficit:        Less than 800


TPN correction:

Optimal re-feeding leads to a gradual increase in total lymphocyte count.




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