Click the Calculate button to determine the total base volume.
Enter the amount of each additive per Bag. Please note the units of measure.
Click the Calculate button to determine the final osmolarity.
To start over again, click the Clear button.
Calcium Phosphate Solubility Curves for Travasol
Click the button below to create a calcium phosphate solubility curve, based on the values entered above, for Travasol brand amino acid.
(solubility curve will appear in new window)
Refer to the following example of a calcium phosphate solubility curve generated by this web site.
Solubility curves are specific for each brand of amino acid.
The three curves refer to the final concentration of amino acid tested (refer to the legend).
The red cross denotes the intersection of Calcium (mEq/L) and Phosphate (mMol/L) concentrations in the TPN solution being evaluated.
If the red cross falls to the right of the appropriate curve, then CaPhos precipitation is likely to occur.
In the following example, one would not expect CaPhos to precipitate out of solution.
However there are many factors other than calcium and phosphate concentrations which influence CaPhos solubility in TPN solutions:
amino acid product formulation
amino acid concentration
admixture final pH
calcium salt form
Because multiple factors influence solubility, the use of inline filtration is required to prevent unrecognized precipitates from reaching the patient.
For TNA (3-in-1) formulations the suggested upper limits are 8.5mEq calcium and 20mMol phosphorous per liter.
For more detailed information on calcium and phosphate solubility:
Lawrence A. Trissel. (2001). Calcium and Phosphate Compatibility in Parentereal Nutrition. Houston, TX: TriPharma Communications.
(out of print).