How to enter a drug model in Kinetics©

Vancomycin 1-compartment model

1. First, you will need to be using build 1.1.6 or higher, improved error checking was added, also previous versions had trouble displaying newly created models.
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2. Start the Edit drug model function by clicking File then Edit from the menu bar or by using the keyboard shortcut Ctrl+E.

3. Click the add button on the database toolbar or use the keyboard shortcut Ctrl+A.

4. Enter the following data in the appropriate fields. You may, of course, use numbers for Vd and Kel which are better suited for your patients.
   Click here to view vancomycin pk models

   Field	Data	Notes
   Drug name	Vancomycin 1cpt	Must be a unique name
   Model type	1	1-compartment model
   Vd peripheral	0.5	Volume of distribution
   Age correct	1	Vd correction for elderly
   Wt correct	0.4	Vd correction for obesity
   Target PK	30	Target peak level
   Target TR	5	Target trough level
   Infusion	60	Infusion rate in minutes
   Renal	.0022	From the Kel equation Kel = Nonrenal + (CrCl x Renal)
   Nonrenal	.009	From the Kel equation Kel = Nonrenal + (CrCl x Renal)
   QD Dose	40	Warning flag for max dose per day
   MIC	5	Minimum inhibibitory concentration
   SD VD	.2	SD for Vd Required for Bayesian
   SD Kel	.4	SD for Kel Required for Bayesian
   CP1	.025	Serum level assay error polynomial Required for Bayesian
   CP2	.01	Serum level assay error polynomial Required for Bayesian
   CP3	.0005	Serum level assay error polynomial Required for Bayesian
   CPfixed	.65	Serum level assay error polynomial Required for Bayesian

   Click here to view a screen shot of the editing screen.

5. Click "Exit" and the program will ask if you want to save the new model, of course you will click yes to save your work.