Other CrCl Methods

This window is used to select alternate creatinine clearance methods.

Select the calculation method, then "Copy" to transfer the value to the patient data tab.

This selection will then be the 3rd CrCl method on each adult patient.

Click "Cancel" to close the window without copying the value to the patient data tab.

Cockcroft and Gault TBW

This variation of the C&G equation uses Total Body Weight instead of Ideal Body Weight.  Be aware however, that this tends to over-estimate CrCl in larger patients.

CrCl Males = TBW(140 - Age) / (SCr x  72)

CrCl Females = 85% of male value

Cockcroft and Gault Normalized

Removes weight from the C&G equation.  Some find this variation useful in patients whose body size is substantially different from average. This is also the method used when "Adjust CL to IBW" is checked.

CrCl Males = (140 - Age) / SCr

CrCl Females = 85% of male value

Jelliffe 1973

Weight is not used in this equation either, therefore, some find this method useful in patients whose body size is substantially different from average:

CrCl Males = 98 - (0.8 x (Age-20)) / Scr

CrCl Females = 90% of male value

MDRD (abbreviated)

Please note: MDRD estimates glomerular filtration rate (eGFR), NOT creatinine clearance. It should not be used to calculate pk models which were derived from CrCl.

This particular equation was derived from a large study of patients with a wide range of kidney function.  Some feel this is a more accurate GFR method overall.

GFR Males = exp[ 5.228 - ( 1.154 x  log{SCr} )  - ( 0.203  x  log{Age} )

GFR Female = 74.2% of male value

For African Americans multiply by 1.21

Salazar and Corcoran

Derived from a study of obese patients.  Some recommend this method for obese patients instead of the standard equations.

CrCl Males  =  { ( 137 - Age ) x [ ( 0.285 x Wt)  + (12.1 x Ht^2 )] }  /  (51 x SCr)

CrCl Females  = { ( 146 - Age ) x [ ( 0.287 x Wt)  + (9.74 x Ht^2 )] }  /  (60 x SCr)