Finished updating rxkinetics.net this week:
- Updated the help files
- Tweaked TPN screens
- Added aztreonam model per request
I had some time to work on a new project for the UK National Poisons Information Service. A professor there had purchased KinPlot. I sent him a note of thanks, he responding by saying “I thought it would help a clinical pharmacology student calculate a half-life which of course it does not!” After more back and forth I agreed to write a little program to estimate half-life and dose for poisoning cases. Inputs are estimated time of ingestion and 2 to 4 level/date pairs. Option to solve for dose or volume of distribution. The program calculates Kel, half-life, Cpmax, and dose (or Vd) using least squares linear regression. Screen shot:
I will be adding graph and report functionality when I find more time. I am thinking about somehow incorporating this into my pk programs. After 30 years I may be able to finally put away the 3-cycle log paper. But then again, I think I would miss it.